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KMID : 0960920020010010044
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Dementia and Neurocognitive Disorders
2002 Volume.1 No. 1 p.44 ~ p.47
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A Case of Biopsy-proven Young-onset Alzheimer’s Disease with Superimposed Parkinsonism
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Choi Eun-Jung
Bang Hyun
Im Joo-Hyuck
Lee Jae-Hong
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Abstract
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Extrapyramidal signs(EPSs) frequently accompany Alzheimer’s disease(AD). However, the pathogenesis or pathologic basis for the EPSs in AD remains unclear. We report a case of presenile onset progressive dementia later associated with
hemiparkinsonism. Brain biopsy showed neurofibrillary tangles and amyloid plaques, compatible with Alzheimer’s disease. There are a few reports about dopamine transporter imaging of AD with EPSs. I-123 IPT SPECT revealed a decreased uptake in both basal ganglia, more severe on the left side and in the caudal putamen, which is consistent with the finding of idiopathic Parkinson’s disease. Alzheimer’s disease and Parkinson’s disease are thought to be coexistent in our patient.
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KEYWORD
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Alzheimer’s disease, Extrapyramidal signs, Parkinson’s disease
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